Reglagene is the product of research coming from the labs of Professor Laurence Hurley at the University of Arizona. Professor Hurley discovered that DNA quadruplexes in gene promoter regions serve as master control elements for gene expression.
RICHARD AUSTIN, PhD, MBA
Chief Executive Officer/President
Dr. Richard Austin is a Pharmaceutical R&D veteran with 25 years of experience ranging from the laboratory bench to management. His professional career began as a medicinal chemist with Burroughs Wellcome (eventually Glaxo SmithKline) in 1993 at its Research Triangle Park, NC site. He took a similar role with Selectide (eventually Sanofi) in 1997. Richard moved into a research operations role in 2011, responsible for managing the operational aspects of Sanofi’s science at its Tucson Research Center. As a member of the site leadership team, he managed R&D operational and capital spending, laboratory equipment maintenance and repair, R&D contract creation, and budget creation. He holds an Organic Chemistry PhD (University of Texas) and an MBA in Pharmaceutical Management (Drexel University). Richard completed postdoctoral training in Bioorganic Chemistry at the University of California at Berkeley. He is an angel investor with Tucson’s Desert Angels and a commercialization partner with the University of Arizona’s technology transfer office.
LAURENCE HURLEY, PhD
Chief Scientific Officer
Dr. Laurence Hurley is leading Reglagene’s application of quadruplex gene expression control to the discovery and development of medicines that combat serious diseases. He has built a distinguished academic career in the study of DNA structure and function leading to the creation and development of therapeutic agents that interact with DNA as anticancer agents and one kinase inhibitor. He is the leading authority drugging quadruplex systems, has published more than 270 peer-reviewed papers, and filed 25 patents. Three products have been discovered in his first company Cylene or in his academic lab that went into human clinical trials (Quarfloxin, CX-5461, Amuvatinib). In addition, sponsored research programs with pharmaceutical companies resulted in three more clinical stage products with reaching the market (Vadastuximab Talirine, Bizelesin, Yondelis [marketed]). Laurence was the first to report that DNA quadruplex structures serve as control elements for gene expression. Laurence believes his latest quadruplex discoveries are the highlight of his career, are ripe for translation, and will result in viable medicines that provide patient benefit. After obtaining his PhD at Purdue University, he completed postdoctoral studies in the Chemistry Department at the University of British Columbia. He has held appointments at the Universities of Maryland, Kentucky, and Texas (Austin), and since 2000 has been at the University of Arizona, where he has served as Associate Director of the BIO5 Collaborative Research Institute and Co-Director of the Molecular Therapeutics Program at the Arizona Cancer Center.
VIJAY GOKHALE, PhD
Vice President of Discovery
Dr. Vijay Gokhale manages Reglagene’s therapeutics discovery operations. He joined Laurence as a postdoc at the University of Arizona in 2003 and contributed to early discoveries in quadruplex drug targeting. Since that time, he has managed the University of Arizona’s campus-wide medicinal chemistry activities, while continuing to discover candidate therapeutic agents that interact with quadruplex systems. His efforts at the University have also provided the intellectual property resulting in the formation of several commercial ventures (e.g., Regulonix, Fibronox). Dr. Gokhale’s primary technical expertise is the application of molecular modeling and computational chemistry techniques in the design and development of therapeutic agents. Dr. Gokhale was a co-founder of Tetragene and is a non-participating founder of Regulonix.
BETTY R WEAVER, CPA PC
Chief Fincancial Officer
Mrs. Weaver has 18 years in public accounting with a regional firm in the Dallas/Fort Worth area and as principal of accounting firms in Texas and Arizona. Her significant focus has been on providing early and expansion-stage companies in Biotech and Life Sciences with planning, analysis, and full CFO services. She also provides state and federal tax planning and preparation services, review services, and consulting services. Clients include domestic and international companies in a wide range of industries, including manufacturing, veterinary clinics, medical practices, and commercial real estate development and construction.
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