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Updated: Feb 27, 2020

Glioblastoma Multiforme (GBM) is the most commonly diagnosed brain cancer in adults. It is insidiously aggressive and is the disease that so quickly took the life of Arizona Senator John McCain. Reglagene’s approach to targeting the TERT gene offers new hope for a better therapy. The TERT gene is mutated in 80% of GBM patients. Patients presenting with the mutated gene have a median survival of 10 months, compared with 20 months for patients presenting with the normal gene. The National Institute of Neurological Disorders and Stroke (NINDS) notified Reglagene of a $400,000 STTR small-business award on April 5, 2019, to enable application of its novel TERT gene-targeting technology to discover and develop a new therapy for GBM. Reglagene’s partner in this effort is Dr. Michael Berens, Professor and Director, Cancer and Cell Biology Division at The Translational Genomics Research Institute (TGen). The Principal Investigator on the award is Reglagene’s CSO Dr. Laurence Hurley.


The envisioned therapeutic agent leverages the action of DNA quadruplex structures to selectively attenuate expression of the TERT gene. Distinguishing the GBM program from Reglagene’s effort to apply this same technology to prostate cancer is that the targeted therapeutic agent must access the brain. This difference is substantial and will require a therapeutic agent with unique characteristics. Successful product development will provide a new therapy for GBM, a disease that has seen limited progress in treatment paradigms over the last several years.


Updated: Feb 27, 2020

Reglagene was one of 10 companies selected out of more than 300 applicants to pitch leaders from across Johnson & Johnson Innovation during the 2019 J.P. Morgan Healthcare Conference. JPM Week occurs annually in January and is the largest gathering of the pharma, biotech, and investor sectors. Johnson & Johnson Innovation launched the Quick Pitch to unearth the unseen and brightest innovations in healthcare. During the event on January 9, 2019, Reglagene made a tightly woven and compelling presentation that also served as the basis for conversations with prospective investors and pharmaceutical partners throughout the week. After the presentation, Johnson & Johnson awarded Reglagene a trophy for its participation. Reglagene’s CSO Laurence Hurley and CEO Richard Austin proudly pose with the prize.


Updated: Apr 24, 2019

Metastatic prostate cancer will kill 27,000 Americans in 2019. Reglagene’s Quadruplex Master Switch Technology enables the development of a new medicine that kills drug-resistant prostate cancer tumor cells by a new mechanism of action. The National Cancer Institute notified Reglagene of a $300,000 STTR small business award on September 19. This award will enable Reglagene to accelerate its effort to translate groundbreaking research targeting the TERT gene from the University of Arizona onto a product development trajectory. The Principal Investigator on the award is Reglagene’s CSO, Dr. Laurence Hurley.


The envisioned therapeutic agent leverages the action of DNA quadruplex structures to selectively attenuate expression of the TERT gene, resulting in cancer cell death in a few days. Successful product development will exemplify a therapeutic paradigm to treat cancer and other life-threatening diseases marked by abnormal changes in gene expression.